There is, but it may involve some custom scripting depending on how generic you want to get. Zenoss has the ability to run custom Powershell scripts and display the results in the event console, but unless you pin it to a specific mailbox you'll need to break out some Python and create it as a ZenPack.

However, if you wanted to use a single mailbox as the canary for the health of the environment, you could add a Data Source to a monitoring template of type Windows Shell, and add a PowerShell script to query that mailbox, then bind the template to an object that represents Office365.